Content of mediatirs of trophotropic systems at psoriastic patients with different degree of severity of clinical event

Abstract

Psoriasis as one of the most widely-spread dermatosis is still an urgent problem of modern dermatology. Aim. To assess, on the different levels of psoriasis’ clinical event, condition of trophotropic system by the detection serotonin’s, histamine’s and histidine’s content in the daily urine. Materials and methods. 97 patients were examined, by the PASI classification: I-35 patients with light degree of severity, II – 32 with mean, III – 30 with severe. Control group – 30 relatively healthy people. Serotonin’s, histamine’s and histidine’s detection were made in one test of daily urine according to the guideline of C.I. Gerasimova. On the first stage their partition were made with the method of column chromatography. Contest was calculated by the fluorescence standard. Results. Received results indicate about considerable participation of histamine reactive system on the psoriasis’ pathogenesis. Implementation of last is connected with strong psycho-emotional stress, which develops at psoriasis patients in the response, first of all, for itching. Discovered trophotropic mediators’ response: histamine and serotonin in the process of psoriasis’ development has adaptive character. Indirect predominance of histamine reactive system above serotonergic system was marked. In psoriasis’ pathogenesis a leading part play disturbances of vegetative mediators’ balance, in the conditions of its progress lead to the deadaptation and development of pathological reaction, which hook up regulative and metabolic processes. Conclusions. Progressing of psoriasis if followed by gradual activation at transition from light to severe degree of clinical event of trophotropic functions. Given results put up a question about modern correction of condition and trophotropic systems at psoriatic patients with the aim of slowing down its progression.