Dynamics of cytokines concentrations in blood serum of larynx squamous carcinoma patients
Date
2016-07-29
Authors
Karmazina, Iryna
Cherniakova, A.
Isaieva, Inna
Hloba, Nataliia
Journal Title
Journal ISSN
Volume Title
Publisher
Joint Meeting of the American Physiological Society and the Physiological Society
Abstract
The pluripotent role of “cytokines network” in inflammation
and tumor dissemination is still the issue of the day. Cytokine
families are investigated to find out the reliable markers for
the prognosis and monitoring of the course of cancer on the
basis of the correlation between their concentrations in the
blood serum and stages of cancer disease. The aim of our
research was to investigate concentrations of TNF-α, IL-1β, IL-6
(proinflammatory), IL-4, IL-1RA (antiinflammatory) in blood
serum of patients with inflammation and different stages of
squamous epithelium carcinoma of the larynx
Description
Therefore, at the initial stages of cancerogenesis TNF-α, IL-1β
and IL-6 may be generated by malignant cells as well as the
“host’s” immune system against the tumor antigens, and
contribute in the tumor proliferation. At the stage of cancer
dissemination proinflammatory cytokines reach their maximum
with the significant drop of the antiinflammatory IL-4
and IL-1RA that confirm the malfunction of organism immune
surveillance. The cooperative examination of pro- and anti-inflammatory
cytokines levels in the blood serum may be useful
biochemical factors for prognosis of carcinoma metastasis.
Keywords
cytokines concentrations, blood serum, larynx squamous, carcinoma
Citation
Dynamics of cytokines concentrations in blood serum of larynx squamous carcinoma patients / I. Karmazina, A. Cherniakova, I. Isaeva, N. Hloba // Physiology 2016 : Abstracts Joint Meeting of the American Physiological Society and The Physiological Society, Dublin, 29–31 July 2016. – [S. l.], 2016. – P. 342.