IGF-1 in prediction of the development of prediabetes in patients with arterial hypertension

Abstract

Insulin-like growth factor-1 (IGF-1) is a polypeptide that is important for the normal flow of cell division processes and the regulation of apoptosis. Its level in the blood serum of patients with arterial hypertension (AH) may have physiological and clinical significance. Recent clinical studies have shown that elevated baseline levels of IGF-1 may be associated with the development of prediabetes. The presence of T2DM in patients with AH is associated with a significant increase in the level of IGF-1 in the blood serum compared to the indicators in patients with an isolated course of AH, which indicates the role of IGF-1 somatomedin in the development of metabolic disorders. The indicator of the level of somatomedin IGF-1 in the blood serum can be considered as an additional marker in the assessment of the risk of developing prediabetes in patients with AH. Prioritizing the diagnosis of risk factors for T2DM in the prediabetes stage can help prevent the development of T2DM and related complications.