Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4- dihydropyrimidine-2(1H)-thiones
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Date
2009
Authors
Kharchenko, Juliya
Detistov, Oleksandr
Orlov, Valeriy
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
We have developed a liquid-phase route for combinatorial synthesis of novel substituted 5-(1,2,4-oxadiazol-5-yl)-3,4 dihydropyrimidine-2(1H)-thiones. Biginelli-type three-component condensation of 1-(3 aryl-1,2,4-oxadiazol-5-yl)acetones, thiourea, and benzaldehydes is shown to result in new 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thione heterocyclic system. If salicylaldehydes are used in this reaction, a mixture of 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones and 11-(1,2,4-oxadiazol-5-yl)-2,3,5,6-tetrahydro-4H-2,6-methano-1,3,5-benzoxadiazocine-4-thiones is formed.
Description
Keywords
1,2,4-oxadiazole, 3,4-dihydropyrimidine, combinatorial synthesis, liquid-phase route
Citation
Kharchenko Juliya V. Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones / Ju. V. Kharchenko, O. S. Detistov, V. D. Orlov // J. Comb. Chem. – 2009. – Vol. 11. – P. 216–219.