Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/808| Title: | Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4- dihydropyrimidine-2(1H)-thiones |
| Authors: | Kharchenko, Juliya Detistov, Oleksandr Orlov, Valeriy |
| Keywords: | 1,2,4-oxadiazole 3,4-dihydropyrimidine combinatorial synthesis liquid-phase route |
| Issue Date: | 2009 |
| Publisher: | American Chemical Society |
| Citation: | Kharchenko Juliya V. Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones / Ju. V. Kharchenko, O. S. Detistov, V. D. Orlov // J. Comb. Chem. – 2009. – Vol. 11. – P. 216–219. |
| Abstract: | We have developed a liquid-phase route for combinatorial synthesis of novel substituted 5-(1,2,4-oxadiazol-5-yl)-3,4 dihydropyrimidine-2(1H)-thiones. Biginelli-type three-component condensation of 1-(3 aryl-1,2,4-oxadiazol-5-yl)acetones, thiourea, and benzaldehydes is shown to result in new 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thione heterocyclic system. If salicylaldehydes are used in this reaction, a mixture of 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones and 11-(1,2,4-oxadiazol-5-yl)-2,3,5,6-tetrahydro-4H-2,6-methano-1,3,5-benzoxadiazocine-4-thiones is formed. |
| URI: | https://repo.knmu.edu.ua/handle/123456789/808 |
| ISSN: | 1520-4766 |
| Appears in Collections: | Наукові праці. Кафедра медичної та біоорганічної хімії |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| JCC_Detistov_Orlov_Harchenko.pdf | 405,83 kB | Adobe PDF |  View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.