Efficacy and safety of inhaled nebulized chemotherapy in treatment of patients with newly diagnosed pulmonary tuberculosis in comparison to standard antimycobacterial therapy
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Date
2017-02-16
Authors
Kuzhko, Mykhailo
Gumeniuk, Mykola
Butov, Dmytro
Tlustova, Tetiana
Denysov, Oleksii
Sprynsian, Tetiana
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Abstract
The objective/background of this work was to study the efficacy and safety of inhaled nebulized chemotherapy in the treatment of patients with newly diagnosed pulmonary tuberculosis in comparison with standard antimycobacterial therapy.
Materials and methods. The study involved 68 patients aged between 20 years and 70 years with newly diagnosed pulmonary tuberculosis. Patients were allocated to two groups. The first (main, n=21) group of patients received standard chemotherapy and further 0.15 g of isoniazid and rifampicin 0.15 g inhaled through a nebulizer, also they received salmeterol 50 mcg + fluticasone propionate 250 mcg at 2 breaths twice a day for 2 months. The second (control, n=47) group of patients received standard chemotherapy, consisting of orally administered isoniazid (0.3 g), rifampicin (0.6 g), pyrazinamide (2 g), ethambutol (1.2 g) with a dose reduction after the intensive phase of the therapy. Theanti-TB drugs were procured through the Ukraine’s centralized national supply system.
Results. Intoxication symptoms in the first group were reduced following 1.39±0.18 months, whereas in the second group intoxication symptoms were reduced following 2.7 ± 0.1 months, p<.001. Moreover, respiratory symptoms regression in the first group was observed following (1.6±0.2) months, whereas in the second group – following (2.5±0.2) months, p<0.05. Bacillary excretion period evaluated within 1 month was reduced, as it was shown by (66.6±10.5 %) in the main group compared to (27.6±6.5%), p<0.05, in the control group. In addition, period of cavities healing was reduced to (2.9±0.2) months in the main group compared to (3.7±0.1) months, p<0.05, in the control group. Residual radiological lung damage findings (large residual changes) were observed in 22 (23.8±9.5 %) patients of the main group versus 24 (51.0±7.2 %) patients in the control group, p<0.05. After completion of treatment scar stenosis of the bronchi II-III art. diagnosed in 3 (14.2±7.8 %) patients main group and 17 (68.0±6.8 %) - control group, p<0.05. The duration of hospital treatment was 2.4±0.4 months in main group and 4.1±0.4 months in control group, p<0.05.
Conclusion. Administration of of inhaled nebulized chemotherapy in patients with newly diagnosed pulmonary tuberculosis resulted in a comparatively quick reduction of disease manifestation.
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Keywords
inhaled nebulized chemotherapy, tuberculosis, pulmonary tuberculosis, treatment of tuberculosis
Citation
Efficacy and safety of inhaled nebulized chemotherapy in treatment of patients with newly diagnosed pulmonary tuberculosis in comparison to standard antimycobacterial therapy / M. Kuzhko, M. Gumeniuk, D. Butov, T. Tlustova, O. Denysov, T. Sprynsian // ICTT 2017 : 19th International Conference on Tuberculosis Therapy, London, United Kingdom during February, 16–17 2017 / International Academy of Science, Energy and Technology. – London, 2017. – P. 1727.