Intrathecal cerium oxide nanoparticles improve functional recovery after experimental subarachnoid hemorrhage: a proof-of-concept study

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dc.contributor.authorKaliuzhka ,Vladyslav
dc.contributor.authorMarkevych, Mykyta
dc.contributor.authorKlochkov, Volodymyr
dc.contributor.authorProkopiuk, Volodymyr
dc.contributor.authorPiatykop, Volodymyr
dc.date.accessioned2026-11-05T17:41:10Z
dc.date.issued2026
dc.description.abstractEarly brain injury following aneurysmal subarachnoid hemorrhage (SAH) is driven by oxidative stress, neuroinflammation, microvascular dysfunction, and neuronal damage. Cerium oxide nanoparticles (CeO₂ nanoparticles) possess regenerative antioxidant properties and may provide sustained scavenging of reactive oxygen species. This proof-of-concept study evaluated whether intrathecal administration of CeO₂ nanoparticles improved functional recovery after experimental SAH.
dc.identifier.citationKaliuzhka VI, Klochkov VK, Prokopiuk VY, Piatykop VO. Intrathecal cerium oxide nanoparticles improve functional recovery after experimental subarachnoid hemorrhage: a proof-of-concept study. Ukrainian Neurosurgical Journal. 2026;32(3):102-15.
dc.identifier.issn2663-9092
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/38726
dc.language.isoen
dc.publisherІнститут нейрохірургії ім.акад. А.П.Ромоданова НАМН України
dc.subjectsubarachnoid hemorrhage
dc.subjectcerium oxide nanoparticles
dc.subjectnanoceria
dc.subjectintrathecal administration
dc.subjectoxidative stress
dc.subjectneurological recovery
dc.subjectopen-field test
dc.subjectearly brain injury
dc.subject2026а
dc.titleIntrathecal cerium oxide nanoparticles improve functional recovery after experimental subarachnoid hemorrhage: a proof-of-concept study
dc.typeArticle

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