Organometric changes of rats thymus after xenobiotics exposure

Abstract

Background. Pollution of the environment and its influence on the body is a very urgent problem for medicine, as it is accompanied with an increase in the incidence among the population. Chronic exposure to some well-absorbed but slowly eliminated xenobiotics can lead to their bioaccumulation in living organisms. Objectives. The aim of the study was conducted todescribe the organometric changes that occur in the thymus of male rats under tryglycidyl ether of polyoxypropylenetriol exposure. Methods. 40 WAG matured male rats were divided randomly into two groups. The first group that constituted 8 animals served as a control. The second group of 32 rats, 8 rodents in each, were treated via gavage by aqueous solutions of TEPPT in does 1/10 LD50 in conversion to 5.75 g/kg during 7, 15, 30, 45 days. All animals were sacrificed on the the term defined by experimental design. Thymus specimens were dissected out and measurements of the linear dimensions (length, width, height) using digital caliper were taken. The mass and volume of the thymus were counted. Limits of the variability of the morphometric indices of the thymus in intact and experimental groups were calculated. Results. The research indicates that tryglycidyl ether of polyoxypropylenetriol exposure caused marked organometric changes in rats thymus.100% effect on all the morphometric indices of the thymus under impact of TEEPT in a dose of 1/10 LD50 on the 7th, 15th, 30th and 45th day was noted. Study revealed that IndH of the control group, which is related to the length and width of the thymus, has the greatest limits of the parameters fluctuations and their significant variability. Ind HW of the thymus of the control group, which is associated with the height and length of the thymus, has the lowest fluctuation limits of the parameters. In our opinion, this is connected, first of all, with the peculiarities of the structure and form of the rats' thymus. Conclusion. Thymus shows active response on the induced xenobiotic and this data can be successfully extrapolated from experimental animals to humans.