Heat shock proteins 70 as markers of complications in children with acute lymphoblastic leukemia

Abstract

Introduction. The mortality rate from complications of acute lymphoblastic leukemia (ALL) in children is high and exceeds the mortality rate from relapse of leukaemia. Ultrahigh expression of HSP 70 is associated with treatment resistance and is an adverse clinical outcome in ALL in children. The objective of the study was to evaluate the dynamics of the level of HSP 70 in the blood serum of children with ALL. Material and methods. 46 children with ALL were studied. Before the start of treatment, the level of HSP 70 in the blood serum has been studied (n = 46). In case of appearance of complications during the conduction of the remission induction, the HSP 70 has been restudied in blood serum (n = 29). Results. HSP 70 is significantly increased in children with ALL. A significant decrease in HSP 70 in the blood serum of patients with induction therapy was revealed compared with the initial level of this protein (p <0.05). No correlation between the level of HSP 70 in the blood serum of children with ALL and the manifestations of chemotherapy complications has been found. In contrast to previous studies, we did not find a significant effect of HSP 70 on mortality. Conclusions. Induction therapy leads to a decrease in the level of HSP 70 in the blood serum of children with ALL. We did not find a direct correlation between the occurrence of complications during induction therapy and HSP 70 concentration in the blood serum.