Apelin – additional marker of insulin resistance

Abstract

Summary: The purpose of the present study was to determine the correlations between the state of carbohydrate metabolism and concentrations of apelin in blood of patients with type 2 diabetes mellitus with different phenotypes. Materials and methods. A total of 32 patients with type 2 diabetes mellitus with different phenotypes (13 men, mean age 56,77 ± 1,79 years) were examined. The control group included 20 healthy individuals. Results. The significant elevation of adipocytokine apelin level was found. The significant correlations between body mass index, apelin and the parameters of carbohydrate metabolism were defined. Conclusions. Increased levels of apelin and connection between this adipocytokine and anthropometric parameters as well as indices of carbohydrate metabolism suggests that elevated body weight contributes to activation and strengthening of impact mechanisms of adipose tissue hormones on metabolic status