Clinical Significance of natriuretic peptides
Date
2022
Authors
Zhuravlyova, Larysa
Sokolnikova, Nelia
Rogachova, Tetiana
Journal Title
Journal ISSN
Volume Title
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Abstract
Natriuretic peptides are widely known for their protective effects against the development of metabolic syndrome and cardiovascular disease. The important role of determining the levels of natriuretic peptides in the diagnosis, assessment of severity, prognosis and effectiveness of treatment of heart failure has been proven in many studies and noted in clinical guidelines worldwide. Visceral obesity reduces the production and action of natriuretic peptides, increasing the risk of heart failure and 2 type diabetes mellitus. Metabolic syndrome is present in 60% of patients with chronic heart failure, most of its components contribute to the development and progression of chronic heart failure and include obesity, hypertension, dyslipidemia, insulin resistance, impaired glucose tolerance. The prevalence of metabolic syndrome in the general population is 34% and is constantly increasing due to unhealthy diet, sedentary lifestyle and chronic stress. The prevalence of chronic heart failure is increasing rapidly in all industrialized countries, affecting 2% of adults and 10% of the elderly. Therefore, the problem of early diagnosis and treatment of metabolic
syndrome and chronic heart failure is relevant nowadays. The review focuses on the pathophysiological relationships between natriuretic peptides, heart failure and metabolic syndrome, and the approaches to the correction of natriuretic peptides’ metabolism.
Description
Keywords
2 type diabetes mellitus, heart failure, metabolic syndrome, natriuretic peptides
Citation
Zhuravlyova L. Clinical Significance of natriuretic peptides / L. Zhuravlyova, N. Sokolnikova, T. Rogachova // Inter Collegas. – 2022. – Vol. 9, No.1. – P. 5–13.