Particularities of inflammatory markers changes in patients with chronic kidney disease complicated with arterial hypertension

Abstract

The aim was to study the dynamics of inflammatory markers CRP, IL-1β, IL-4, TNF-α − under the influence of hypertension in patients with CKD. Methods: Included in the study 56 patients with CKD, the first group (n=27) was represented by patients with high blood pressure (BP) systolic blood pressure> 140 mm Hg., BP diastolic <90 mm Hg., the second group - patients with CKD and normal values of BP. The control group consisted of 20 healthy individuals. Cytokines and CRP levels were determined by ELISA. Results and discussion. Revealed a significant increase of inflammatory markers CRP, IL-1β, TNF-α in patients with CKD compared with the control group, whereas anti-inflammatory IL-4 was reduced. For chronic kidney disease with hypertension were characterized by the increasing in CRP, TNF-α and IL-1β and decreasing of anti-inflammatory interleukin-4. It is important to note, that in comparison with the group of patients with normal pressure, patients with hypertension had significantly elevated levels of TNF-α (65,25 ± 4,57, p<0,05). Conclusions. Joining hypertension to CKD leads to greater activation of the inflammatory process in these patients. The level of anti-inflammatory IL-4 was almost equally low in both groups, compared with controls, regardless of the presence of hypertension.