Наукові роботи молодих вчених. Кафедра внутрішніх та професійних хвороб
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Item Lung hyperinflation - a prognostically significant marker in geriatric patients(2024-04) Ananya DwivediLung hyperinflation is a common finding in patients with chronic obstructive pulmonary disease (COPD) observed via plain radiograph. Among people older than 65 years, the risk of developing COPD increases five times compared to 40 year olds (Easter M. et al., 2020). In addition, hyperinflation may be found in patients with the Tiffeneau index > 0,7. In most cases, this radiological finding is not given due attention, therefore further diagnosis and treatment is either delayed or insufficiently carried out.Item A modern view on hyperkalemia’s management(2023-10) Melenevych, Anastasiia; Dwivedi, AnanyaThe study demonstrated that sodium polystyrene sulfonate (SPS) and calcium polystyrene sulfonate (CPS) have dominated the management of hyperkalemia over 6 decades after being approved by the United States Food and Drug Administration (FDA) in 1958 because of their long term effi cacy but due to their affi liation with gastrointestinal side effects their usage has been insubstantial or limited. Earlier SPS was thought to work effectively for constipation along with sorbitol but later FDA found it to be causing colonic necrosis and increased mortality. CPS was useful in patients with high sodium load but there were cases with increased vascular calcifi cation. So, eventually in 2009, the FDA prohibited their long-term use for hyperkalemia. The shortcomings led to the development of “new generation” potassium binders including - patiromer and sodium-zirconium cyclosilicate (SZC / ZS-9). In clinical studies patiromer was found to be well tolerated and reduced hyperkalemia in patients with diabetes mellitus, chronic kidney disease, heart failure, hypertension to enhance cardiovascular and renal outcomes and also in patients on renin-angiotensin-aldosterone system inhibitors (RAASi) therapy. Cochrane reviews were conducted three times (2005, 2015, and 2020) for comparison of “old generation” potassium binders with the new generation” potassium binders however, from the point of view of safety, preference was given to the “new generation” potassium binders.Item Взаимосвязь артериальной гипертензии и уровня провоспалительных цитокинов при метаболическом синдроме(ХНМУ, 2014-01-14) Шелест, Борис Олексійович; Шатилова, Ю.И.; Ковалева, Ю.А.Повышение продукции фактора некроза опухоли альфа и интерлейкина-1 бета у пациентов с артериальной гипертензией и метаболическим синдромом ассоциируется с развитием ремоделирования миокардаItem Рівень про- та протизапальних цитокінів у хворих на хронічне обструктивне захворювання легень(ХНМУ, 2014-01-14) Архіпкіна, Ольга Леонідівна; Введенська, А. Є.; Поляков, О. В.Встановлено порушення балансу імунорегуляторних цитокінів (ФНП-а, ІЛ-10) у хворих на хронічне обструктивне захворювання легенів у бік хронізації запального процесу