Hormone-like cytokines in patients with non-alcoholic steatohepatitis and hypertension

Abstract

The hormone-like cytokines are considered crucial players in inflammatory-associated disorders. Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation and in a substantial subset of patients with inflammation in the liver – non-alcoholic steatohepatitis (NASH) development. Such cytokines play a central role in many stages of liver diseases mediating fundamental aspects of those diseases like lipid metabolism, cholestasis, fibrosis and, also, regulate crucially the development of insulin resistance.Serum FGF21 is significantly higher in NASH patients with HT, its levels correlated with markers of lipid and carbohydrate metabolism and predict subclinical atherosclerosis. FGF21 is a potential marker of NASH progression.