Regulation of cytokine levels during comprehensive treatment of patients with generalized periodontitis using various forms of quercetin

Abstract

While the exact contribution of each cell type remains to be elucidated, previous studies described that a hyper-reactive phenotype of phagocytes is related to increased pro-inflammatory cytokines production in CGP. The cytokine level of the patients of control group was TNF-α - 21,71 ± 2,95 pg/ml, where as that of the anti-inflammatory was ІL-4 - 243,5 ± 17,48 pg/ml. As such, numerous gingival crevicular fluid (GCF) constituents have been characterized to identify biomarkers that may be used to monitor the initiation and progression of gingival inflammation and the immune response.