Interrelation of the gene CDKN1A (RS 1801270) polymorphic state аnd level of development of caries in children with Down syndrome

dc.contributor.authorNazaryan, R.
dc.contributor.authorIskorostenskaya, O.
dc.contributor.authorGorenskaya, O.
dc.contributor.authorVolkova, N.
dc.contributor.authorGargin, Vitaliy
dc.date.accessioned2018-11-27T09:11:54Z
dc.date.available2018-11-27T09:11:54Z
dc.date.issued2018
dc.description.abstractStudy is devoted for rs1801270 polymorphism of CDKN1A gene due to the level of intensity of caries development in children with Down syndrome. The full development of oral cavity organs is ensured through a complex of genes whose protein products control different stages of this difficult process. Changes in gene structure, as well as disturbance of their expression may lead to abnormalities of development of teeth and periodontal tissues. Analysis of the polymorphism of CDKN1A gene Ser31Arg in children living in Kharkiv region has shown that the frequency of genotypes and alleles corresponds to the theoretically expected distribution by Hardy-Weinberg in the core (χ2=0.12) and control (χ2=1.29) groups. There is no significant differences in the frequency of alleles of CDKN1A gene in the group of healthy children and children with Down syndrome (p=0.978). There is an association of heterozygous option C/A of the studied marker Ser31Arg of CDKN1A gene with the level of intensity of caries development (by Leus) in children with Down syndrome under 10 years old.ru_RU
dc.identifier.citationInterrelation of the gene CDKN1A (RS 1801270) polymorphic state аnd level of development of caries in children with Down syndrome / R. Nazaryan, O. Iskorostenskaya, O. Gorenskaya [et al.] // Georgian Medical News. – 2018. – N 2 (275). – Р. 112–116.ru_RU
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/21367
dc.language.isoenru_RU
dc.subjectcariesru_RU
dc.subjectCDKN1Aru_RU
dc.subjectgeneru_RU
dc.subjectSer31Argru_RU
dc.subjectchildrenru_RU
dc.subjectDown syndromeru_RU
dc.titleInterrelation of the gene CDKN1A (RS 1801270) polymorphic state аnd level of development of caries in children with Down syndromeru_RU
dc.typeArticleru_RU

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Гаргин-2.pdf
Size:
924.66 KB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
11.51 KB
Format:
Item-specific license agreed upon to submission
Description: