Features of the structural and functional state of blood lymphocytes in patients with infectious mononucleosis with different course

Abstract

The relevance of the problem of infectious mononucleosis (IM) is determined by the high level of Epstein-Barr virus (EBV) infection in children, the possibility of developing an unfavorable course of the disease and, in some cases, the formation of long-term immunosuppression with a deficiency of T-cell and phagocytic immunity. The available literature clearly highlights the issues of etiology, pathogenesis and clinical manifestations of the disease. However, scientists' data on the early diagnosis of infectious mononucleosis are rather contradictory. Untimely diagnosis of active forms of EBV infection, and hence untimely treatment, can lead to uncontrolled proliferation of B-lymphocytes, which is a causative factor in the malignancy of EBV-infected cells with the development of lymphoproliferative diseases.