Risk related cardiovascular changes in metabolically healthy obese adolescents
Date
2016
Authors
Chaychenko, Tetyana
Journal Title
Journal ISSN
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Abstract
Background: Pediatric obesity reflects a real crisis for public health as
associated with cardiovascular risk in subjects with developed metabolic
syndrome. Simultaneously the information concerning risk related
cardiovascular changes in metabolically healthy obese adolescents is pretty
insufficient.
Methods: 208 obese adolescents were grouped as metabolically healthy and
metabolically unhealthy by IDF criteria for pediatric metabolic syndrome. We
analyzed the basic metabolic parameters, left ventricular geometry and function,
24-hours BP monitoring and carotid intima-media thickness. Control group
consisted of 23 lean healthy subjects.
Results: 69% of obese adolescents could be considered as metabolically healthy
by pediatric IDF criteria. BMI in metabolically unhealthy was greater vs.
metabolically healthy (p=0,019) as well as dyslipidemia and dysglicemia.
Cardiovascular parameters were deteriorated in all obese vs. lean healthy
(myocardial hypertrophy and dysfunction, thickening of carotid vessels and
systolic hypertension). It established low sensitivity (Se = 0,28) and low
negative predictive value (NPV=0,29) of metabolic syndrome criteria to screen
obesity associated cardiovascular problems.
Conclusion: Prognostic capability of pediatric metabolic syndrome criteria is
pretty low due to its sensitivity. Therefore obese adolescents not met diagnostic
level for metabolic syndrome by IDF criteria could be falsely excluded from the
cardiovascular risk group. Thus, it’s not possible to assert an existence of
absolutely healthy metabolic profile in obese and more sensitive markers are
necessary for the metabolically healthy obesity identification.
Description
Keywords
cardiovascular risk, metabolic syndrome, metabolically healthy obese, adolescents
Citation
2. Chaychenko T. Risk related cardiovascular changes in metabolically healthy obese adolescents [Electronic resource] / T. Chaychenko // Polish Annals of Medicine. – 2016. – February, 28. – DOI : http://dx.doi.org/10.1016/j.poamed.2016.01.006.