Correction of Diabetic Dyslipidemia in Patients with Ischemic Heart Disease and Type 2 Diabetes Mellitus

Abstract

In patients with T2DM cardiovascular risk increased 10 times compared with age-matched persons without diabetes. Such patients constitute a group of very high cardiovascular risk because 75% of death cases are due to cardiovascular disease. Prevalence of coronary artery disease in patients with T2DM reaches 50-60%. However, in spite of current standards of medical care, including the achievement of target levels of low-density lipoprotein cholesterol (LDL), intensive control of blood pressure and glucose levels, patients with CHD with concomitant T2DM are at significant risk of macrovascular events and microvascular complications, which is primarily associated with the presence of atherogenic diabetic dyslipidemia, which is characterized by increased very LDL and related increase in triglycerides, small dense LDL cholesterol and lower high density lipoprotein cholesterol levels