Metabolic and histological features of dental tissue in adult rat offspring in maternal hypokinesia
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Abstract
Dental caries is one of the most common diseases
worldwide whose occurrence in children and adolescents has
dramatically increased over the past 10 years. It is important to
gain better understanding of causes, risk actors, preventions,
and associations of tooth decay. This study elucidates a possible
mechanism for the predisposition for tooth decay in postnatal
ontogenesis in the offspring of hypokinetic pregnant
females with regard to the biochemical features of hard dental
tissues, calcium-regulating hormones, and histological examination
of both hard dental tissues and tooth pulp. Maternal
hypokinesia during pregnancy leads to several deficiencies in
the progeny, including hypoplasia of odontoblasts and dentinal
tubules of teeth, decreases in the collagen levels in dentin,
low blood serum levels of parathyroid hormone, and decreases
in calcium concentrations in serum and hard dental
tissues, all of which determine predisposition to tooth decay.
Therefore, maternal hypokinesia during pregnancy is a risk
factor for increased dental caries development in the offspring.
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Metabolic and histological features of dental tissue in adult rat offspring in maternal hypokinesia / G. I. Gubina-Vakyulyk, T. V. Gorbach, M. S. Baranova, A. S. Tkachenko, S. A. Denysenko // Comparative Clinical Pathology. – 2017. – № 26. – Р. 1329–1334.