The interrelation between diastolic dysfunction and interleukin-1β level in patients with diabetic cardiomyopathy

Abstract

The formation of diabetic cardiomyopathy against the background of diabetes mellitus type 2 is associated not only with insulin resistance, hyperinsulinemia and glucose toxicity, but also with the activation of proinflammatory cytokins. One of the mediators of inflammation is interleukin-1β, which is the marker of severity and the predictor of the development of cardiovascular diseases. However, the extent of IL-1β involvement into the development of diastolic dysfunction, typical for metabolic cardiomyopathy, is not well studied.