Genetic markers of arterial hypertension prognosis in patients with diabetes mellitus type 2

Abstract

The European Society of Cardiology in its recommendations noted that the development of arterial hypertension (AH) is due to the presence of a large number of mutations in genes that monitor the main blood pressure monitoring systems. That is, AH is considered as a highly heterogeneous disease with a multifactorial etiology and polygenic changes. The prevalence of the disease is so high (up to 30% of the world’s population), the complications that arise are so serious and arterial pressure in most cases remains uncontrollable, that the disease is considered to be socially significant, which affects not only the quality of life, but also the mortality of patients. The high prevalence among all causes of morbidity allows to assume its combination with other diseases of internal organs, among which a special place is occupied by diabetes mellitus (DM). The defeat of the vascular system against the background of changes in all types of metabolism leads to serious complications when combined. Purpose: diagnostic optimization of the combined course of AH and type 2 diabetes mellitus by establishing the role of the ACE and NOsynthase genes polymorphism.