The level of neuroactive amino acids in blood plasma of psoriatic patients

Abstract

Some amino acids neurotransmiters, such as glutamate, aspartate, glycine and γ-аminobutyric acid may be involved in the pathogenesis of psoriasis and hypertension. But their relationship with dermatosis severity and comorbidites are unclear. The aim of this study was to quantify level of activating and inhibitory amino acids in blod plasma of the patients sufering from isolated psoriasis and psoriasis combined with hypertension depending on severity of disease. The study was conducted on two groups of patients, first group consisted of 74 patients with isolated psoriasis, second group consisted of 48 patients with psoriasis combined with hypertension, control group comprised 30 practicaly healthy patients. Blod plasma level of glycine, glutamate, aspartate and γ-aminobutyric acid were defined by liquid chromatographic analysis. Severe course of psoriasis, especialy combined with hypertension is characterized by excitatory and inhibitory mechanisms imbalance with signs of protective inhibiton insuficiency; deficiency of GABAergic protective mechanisms along with increased release of excitatory amino acids determines the severity of psoriasis in this contingent of patients. Changes of the level of excitatory and inhibitory amino acids in blod plasma of psoriatic patients indicate their obvious participation in formation of cerebral circulation disturbance and autonomic regulation of peripheral vesels disorder.