TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis

dc.contributor.authorSkliar, Anna
dc.contributor.authorKoliada, Oleg
dc.contributor.authorVdovichenko, Nataliya
dc.contributor.authorKoliada, Tetyana
dc.date.accessioned2020-11-20T09:15:23Z
dc.date.available2020-11-20T09:15:23Z
dc.date.issued2020
dc.description.abstractPhagocytic activity lesions of monocytes were observed both in patients with RRMS and PMS, associated mainly with FcR-mediated mechanisms of phagocytosis. IFN-β therapy in patients with RRMS led to the correction of such disorders in patients with high treatment efficacy (responders), and TLR7/8-mediated activation of monocytes was accompanied by an increase in the number of phagocytic cells. In patients with low efficacy of IFN-β therapy (nonresponders), the nature of changes in the phagocytic activity of stimulated monocytes indicated a decrease in the functional reserve with regard to FcR-mediated phagocytosis. The obtained results indicate differences in phagocytic activity indices during stimulation of TLR4 and TLR7/8 and may indicate the presence of functional and phenotypic alterations of peripheral blood monocytes depending on the ef¬fectiveness of MS treatment.en_US
dc.identifier.citationTLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis / A. I. Skliar, O. M. Koliada, N. I. Vdovichenko, T. I. Koliada // Патологія. – 2020. – Том 17, № 2 (49). – C. 288–233. – DOI: 10.14739/2310-1237.2020.2.212807.en_US
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/27403
dc.language.isoenen_US
dc.subjectmultiple sclerosisen_US
dc.subjectTOLL-like receptorsen_US
dc.titleTLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosisen_US
dc.title.alternativeTLR-опосередкована активація фагоцитозу моноцитів периферичної крові у хворих на розсіяний склерозen_US
dc.typeArticleen_US

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