TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis
dc.contributor.author | Skliar, Anna | |
dc.contributor.author | Koliada, Oleg | |
dc.contributor.author | Vdovichenko, Nataliya | |
dc.contributor.author | Koliada, Tetyana | |
dc.date.accessioned | 2020-11-20T09:15:23Z | |
dc.date.available | 2020-11-20T09:15:23Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Phagocytic activity lesions of monocytes were observed both in patients with RRMS and PMS, associated mainly with FcR-mediated mechanisms of phagocytosis. IFN-β therapy in patients with RRMS led to the correction of such disorders in patients with high treatment efficacy (responders), and TLR7/8-mediated activation of monocytes was accompanied by an increase in the number of phagocytic cells. In patients with low efficacy of IFN-β therapy (nonresponders), the nature of changes in the phagocytic activity of stimulated monocytes indicated a decrease in the functional reserve with regard to FcR-mediated phagocytosis. The obtained results indicate differences in phagocytic activity indices during stimulation of TLR4 and TLR7/8 and may indicate the presence of functional and phenotypic alterations of peripheral blood monocytes depending on the ef¬fectiveness of MS treatment. | en_US |
dc.identifier.citation | TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis / A. I. Skliar, O. M. Koliada, N. I. Vdovichenko, T. I. Koliada // Патологія. – 2020. – Том 17, № 2 (49). – C. 288–233. – DOI: 10.14739/2310-1237.2020.2.212807. | en_US |
dc.identifier.uri | https://repo.knmu.edu.ua/handle/123456789/27403 | |
dc.language.iso | en | en_US |
dc.subject | multiple sclerosis | en_US |
dc.subject | TOLL-like receptors | en_US |
dc.title | TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis | en_US |
dc.title.alternative | TLR-опосередкована активація фагоцитозу моноцитів периферичної крові у хворих на розсіяний склероз | en_US |
dc.type | Article | en_US |
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