TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis

Abstract

Phagocytic activity lesions of monocytes were observed both in patients with RRMS and PMS, associated mainly with FcR-mediated mechanisms of phagocytosis. IFN-β therapy in patients with RRMS led to the correction of such disorders in patients with high treatment efficacy (responders), and TLR7/8-mediated activation of monocytes was accompanied by an increase in the number of phagocytic cells. In patients with low efficacy of IFN-β therapy (nonresponders), the nature of changes in the phagocytic activity of stimulated monocytes indicated a decrease in the functional reserve with regard to FcR-mediated phagocytosis. The obtained results indicate differences in phagocytic activity indices during stimulation of TLR4 and TLR7/8 and may indicate the presence of functional and phenotypic alterations of peripheral blood monocytes depending on the ef¬fectiveness of MS treatment.