Study of the role of proinflammatory cytokines in the progression of diabetic nephropathy

Abstract

In the progression of diabetic nephropathy (DN), great importance is attached to immune factors, in particular, the cytokine system, which is a universal polymorphic regulatory network of mediators that control the proliferation and differentiation of cellular elements in hematopoietic, immune and other homeostatic systems. The role of proinflammatory cytokines in the development and progression of DN is almost unexplored, so the authors studied the role of proinflammatory cytokines in DN at different degrees of the functional state of the kidneys. Results of the presented studies indicate that pro-inflammatory cytokines play an important role in the progression of DN, contribute to the development of sclerotic processes in the kidneys. Indicators of IL-1α and TNF-α levels can be used as markers of progression of DN and criteria for the prognosis of this common and dangerous disease. The study of cytokines in DN can be useful for deepening knowledge of the mechanisms of pathogenesis, the development of criteria for its progression and prognosis, as well as to develop new approaches to the treatment of this common and dangerous complication of diabetes mellitus.