Challenges of adaptation to physiological factors in persons with sickle cell disease
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Date
2017-05
Authors
Asiome, W.
Karmazina, Iryna
Isaieva, Inna
Journal Title
Journal ISSN
Volume Title
Publisher
Харьковский национальный медицинский университет
Abstract
Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive
events and chronic hemolytic anemia which result in tissue ischemia leading to acute
and chronic pain as well as injuring of bones, lungs, liver, kidneys, brain, eyes, and
joints. About 50 % of children with SCD experience either an overt or silent cerebral
infarct; hemorrhagic stroke and aneurysm are more common in adults
Description
1. Analysis of reported figures has indicated that patients with SCD have
limited abilities for adaptation to different physiological factors.
2. Such physiological factors as physical exercises, hypoxia, dehydration, extreme
temperatures and high are beneficial for polymerization of HbS resulting in progression
of sickle RBCs hemolysis, increase of hypoxia severity and oxidative stress that
significantly impact disease prognosis and outcome. 3. When these factors are brought
under control it will ultimately augment measures aimed at managing the clinical
disorders of sickle cell disease.
Keywords
sickle cell disease, (SCD), vaso-occlusive events
Citation
Asiome W. Challenges of adaptation to physiological factors in persons with sickle cell disease/ W. Asiome, I. Karmazina, I. Isaeva // 10th International Scientific Interdisciplinary Conference (ISIC) for medical students and young scientists, Kharkiv, 19–20 May 2017 : аbstract book / KhNMU. – Kharkiv, 2017. – P. 6.