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http://repo.knmu.edu.ua/handle/123456789/18097| Title: | Challenges of adaptation to physiological factors in persons with sickle cell disease |
| Authors: | Asiome, W. Karmazina, Iryna Isaieva, Inna |
| Keywords: | sickle cell disease (SCD) vaso-occlusive events |
| Issue Date: | May-2017 |
| Publisher: | Харьковский национальный медицинский университет |
| Citation: | Asiome W. Challenges of adaptation to physiological factors in persons with sickle cell disease/ W. Asiome, I. Karmazina, I. Isaeva // 10th International Scientific Interdisciplinary Conference (ISIC) for medical students and young scientists, Kharkiv, 19–20 May 2017 : аbstract book / KhNMU. – Kharkiv, 2017. – P. 6. |
| Abstract: | Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia which result in tissue ischemia leading to acute and chronic pain as well as injuring of bones, lungs, liver, kidneys, brain, eyes, and joints. About 50 % of children with SCD experience either an overt or silent cerebral infarct; hemorrhagic stroke and aneurysm are more common in adults |
| Description: | 1. Analysis of reported figures has indicated that patients with SCD have limited abilities for adaptation to different physiological factors. 2. Such physiological factors as physical exercises, hypoxia, dehydration, extreme temperatures and high are beneficial for polymerization of HbS resulting in progression of sickle RBCs hemolysis, increase of hypoxia severity and oxidative stress that significantly impact disease prognosis and outcome. 3. When these factors are brought under control it will ultimately augment measures aimed at managing the clinical disorders of sickle cell disease. |
| URI: | https://repo.knmu.edu.ua/handle/123456789/18097 |
| Appears in Collections: | Наукові роботи молодих вчених. Кафедра фізіології |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ISIC-исаева.pdf | 2,25 MB | Adobe PDF |  View/Open |
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