Медіатори запалення та регуляторні гормони у дітей з виразковою хворобою

Abstract

Background and Aims: To analyze the state of the profile of inflammatory mediators and regulatory hormones in children with various variants of the course of duodenal ulcer (DU). Methods: 47 children aged 7–15 years with DU were examined. In 23 (48.9%) there was a newly diagnosed uncomplicated Hp+ DU, in 24 (51.1%) an unfavorable type of disease course was established with complications, frequent relapses of Hp- DU. The level of pro-inflammatory cytokines (IL-1; IL-2; IL-8) in the peripheral blood was determined by ELISA, gastrin (G) and somatostatin (ST) – by radioimmunological method, Helicobacter pylori (Hp) by histology. Results: Changes in the cytokine profile were ambiguous in children with different variants of the course of DU. With a favorable course and timely repair of the ulcer, the level of IL-1 and IL-8 increased moderately in 54% of children, and the level of IL-2 increased slightly in 32% of patients. Variants of complicated, frequently recurrent DU were characterized by a significant and persistent increase (2–3 times) in the levels of predominantly IL-8 and IL-1 (p <0.01). The study of the hormonal profile revealed varying degrees of hypergastrinemia, which was persistent and pronounced in recurrent and complicated DU. The CT level was predominantly in the normal range with a favorable course of DU. A significant (p <0.05) decrease in the level of CT was detected in children with frequent relapses, mainly with HP negative DU (in 67% of patients). Conclusions: Changes in cytokine and hormonal profiles are ambiguous in children with different variants of the course of DU.