Hemodynamically significant patent ductus arteriosus and functional state of the myocardium in preterm children

Abstract

The study involved examination of 125 newborns at gestational age of 24-37 weeks. According to Doppler echocardiography findings preterm infants with hemodynamically significant patent ductus arteriosus (HSPDA) were found to have dilation of the left ventricle with hypertrophy of the wall and ventricular septum in 75.9% (p<0.05), dilation of the right ventricular cavity in 82.8% (p<0.05), dilation of the left atrium in 100% (p<0.05), 1st-2nd degree tricuspid and pulmonic regurgitation in 65.5% (p<0.05), Pmean AP>34 mm Hg in 79.3% (p<0.05), disorders of diastolic function of the left and right ventricles (delayed relaxation) were observed in 100% children. Newborns with HSPDA were shown to have lower rates of velocity of fibrous rings and an increased index of global myocardial function. Advanced DEchoCG criteria for HSPDA diagnosis can be effective as part of the plan for screening preterm infants. TissueDoppler imaging in preterm infants with HSPDA is useful in assessing the global function of the myocardium.