Role of adenosine monophosphate-activated protein kinase as a regulator of cell energy balance in patients with metabolic disorders. Literature review

Abstract

The combination of diabetes mellitus type 2 and gout is common. It has been established that prolonged hyperuricemia leads to insulin resistance and suppresses the effects of insulin, which is why the study of pathogenetic links in the formation of metabolic disorders in synergistic pathologies is relevant. AMPK has been shown to be a regulator of cell energy balance, which plays an important role in preventing the development of insulin resistance. The purpose of this review is to determine the impact of AMPK on carbohydrate, lipid and purine metabolism in patients with diabetes mellitus type 2 and gout. The realization of the effects of AMPK on metabolic processes in the human body occurs in two main ways — inhibition of anabolism and stimulation of catabolism, which will be discussed in the article. It is advisable to consider the mechanisms of action of indirect activators of AMPK as potential components for the comprehensive treatment of patients with metabolic disorders.