The role of tumor necrosis factor-alfa in pathogenesis of nonalcoholic fatty liver disease

Abstract

Tumor necrosis factor-α (TNF-α) is an adipokine that can cause the cytotoxic effects and can stimulate the apoptosis, impairing liver function. There is a need in further study of TNF-α influence on liver cells properties and its role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) against the background of diabetes mellitus (DM) type 2 and obesity. Purpose. To assess the correlation between TNF-α and indexes of liver function in patients with NAFLD combined with DM type 2 and obesity.