PPARγ, AT1R and ace gene polymorphisms in relation to hypotensive therapy effectiveness in hipertensive patients with obesity and/or type 2 diabetes mellitus

Abstract

The best sensitivity to treatment with telmisartan was shown by ProPro homozygotes, the presence of Ala-allele and C-allele of AT1R gene was associated with decreased response. HAla /AC+CC seem to be the most unfavorable combination of genes in terms of telmisartan effectiveness in patients with hypertension and DM II. In hypertensive patients with obesity the best response to treatment with ramipril was observed in patients with II genotype of ACE gene, and in DD carriers with indapamide.