Efficacy and safety of parenteral anti-tuberculosis therapy of patients with TB meningitis compared to standard treatment
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Date
2017-10-11
Authors
Kuzhko, Mykhailo
Gumeniuk, Mykola
Butov, Dmytro
Tlustova, Tetiana
Sprynsian, Tetiana
Denysov, Oleksii
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Abstract
Background: The objective of this work was to study the efficacy and safety of parenteral anti-TB therapy in treatment of patients with TB meningitis in comparison with standard antimycobacterial therapy.
Methods: The study involved 44 patients with TB me¬ningitis. Patients were allocated to two groups. The first (control) group (n=31) received standard anti-TB the¬rapy (isoniazid 0.3 g), rifampicin (0.6 g), pyrazinamide (2 g) and ethambutol (1.2 g) - per os. The 2nd (main) group (n=13) received parenteral anti-TB therapy (iso¬niazid 0.5 g) - i/m, rifampicin (0.6 g) - i/v, ethambutol (1.0 g) - i/v and pyrazinamide
(2 g) - per os.
Results: After a week of chemotherapy 5 (16.1±6.6%) patients from 1st group and 10 (79.9±12.1%) patients from 2nd group had a positive dynamics: a decrease in the severity of cerebral symptoms, a decrease in focal neurological symptoms, liquorological and liquorody¬namic changes (19.3±3.8%), pleocytosis (22.9±7.2%) and cerebrospinal pressure to (210±30) mm.v.st.) and intoxication syndrome
(p< 0.05). After two weeks of anti-tuberculosis the¬rapy, improvement of these parameters was observed in 10 (32.2±8.4%) patients of the 1st group and 11 (84.6±10.4%) - 2nd groups (p< 0.05). The mortality rate was significantly lower in the 2nd group (1 patient (7.6±7.6%)) compared to 8 patients of the 1st group (25.8±7.8%),p < 0.05. In addition, parenteral anti-TB therapy provided reduction of side effects by 23%.
Conclusions: Administration of parenteral anti-TB the¬rapy in patients with TB meningitis resulted in a com¬paratively quick reduction of disease manifestation and reduce mortality.
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Keywords
TB meningitis, standard antimycobacterial therapy
Citation
Efficacy and safety of parenteral anti-tuberculosis therapy of patients with TB meningitis compared to standard treatment / M. Kuzhko, M. Gumeniuk, D. Butov, T. Tlustova, T. Sprynsian, O Denysov // 48th World Conference on Lung Health of the International Union Against Tuberculosis and Lung Disease, Guadalajara, Mexico, 11–14 october 2017 / TB Union. – Mexico, 2017. – P. 271.