Parameters of glucose homeostasis and their relationship with xanthine oxidase activity in patients with type 2 diabetes

Abstract

The study aims to determine the associations between clinical and anthropometric parameters and parameters of glucose homeostasis and serum XO activity in patients with T2DM taking into account gender, glycemic control and serum XO activity. Material and methods. 125 T2DM patients aged 34 to 81 years, average age (58.9±9.4) years with disease duration from 1 month to 29 years, average (8.9±6.6) years were examined.Research results. It has been found that in the total group of examined patients with T2DM serum UA depends on serum XO activity (r =0.34; p=0.007). This dependence is described by a linear model: Serum UA (μmol/L) = 324.3+22.7 x serum XO activity (nmol/min/ml), where serum XO activity determines 34% variability of serum UA. Conclusions: 1. In patients with T2DM, the serum UA is linearly associated with the level of serum XO activity, which determines 34% of its variability. 2. In patients with T2DM, regardless of the state of glycemic control, serum XO activity is nonlinearly associated with parameters characterizing the state of glucose homeostasis (fasting insulin, HOMA_% S, HOMA_% β, indexes QUICKI and Caro). 3. Patients with T2DM with high serum XO activity have significantly higher fasting insulin, fasting β-cell secretory activity, low fasting insulin sensitivity, and more pronounced manifestations of IR compared with patients with normal serum XO activity. 4. The level of serum XO activity in patients with T2DM, regardless of the state of glycemic control is determined by serum UA (t=2.52; p=0.02) and WC/HC (t=-2.87; p=0.007). 5. In patients with T2DM with optimal glycemic control serum XO activity determines the fasting insulin (t=2.68; p=0.015), with suboptimal glycemic control and high risk - the patient's age (t=-2.74; p=0.015) and the HOMA_IR index (t=2.62; p=0.02). 6. Predictors of high serum XO activity in patients with T2DM are the level of PBG (t=-3.53; p=0.004) and serum UA (t=4.73; p=0.0005).