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http://repo.knmu.edu.ua/handle/123456789/7805| Title: | The long-term influence of oxyethylized nonylphenols and their derivaties on the cellular and humoral factors of nonspecific immune resistance of the rats organism |
| Authors: | Marakushyn, Dmytro Zhukov, Viktor |
| Keywords: | long-term influence rats nonylphenols DL50 |
| Issue Date: | 2014 |
| Citation: | Marakushin D. I. The long-term influence of oxyethylized nonylphenols and their derivaties on the cellular and humoral factors of nonspecific immune resistance of the rats organism / D. I. Marakushin, V. I. Zhukov // Nauka i Studia. – 2014. – № 8. – P. 69–77. |
| Abstract: | The research of xenobiotics mechanisms of action, development of the scientifically grounded diagnostic programs and detection of the objective prognostic criteria of pathological processes is one of the priority tasks of modem medicine [1, 2]. It is refered in a full degree to oxyethylized nonylphenols (OENP) and their derivatives - sodium salts of carboxymethylates of oxyethylized isononylphenols (CM-OENP), winch have physical and chemical properties and features of structure of molecules like ionogenic detergents. These substances are characterized by considerable output volumes of synthesis, wide usage in different industries of national economy (as basis of industrial issue of plastics, polyurethanes, cleaning agents, emulsifying agents, anticorroding preparations, hydraulic and cooling fluids, and others like that), entry to the sources of water consumption and due to it possible influence on the organism of man [3, 4]. Mechanisms of OENP and their derivatives action are studied not enough. Their revelation is the base for explanation of measures on the conservation of the environment and health activities. |
| Description: | The long-term intoxication of the rats organism by OENP and their derivatives in doses 1/10 and 1/100 DL50 causes the change of indexes of nonspecific immune resistance, that is confirmed by disturbance of leukogram, phagocytic activity of neutrophils due to the decrease to tire percent of phagocytosis, phagocytic index, absorption index and digestion index of staphylococci, by reduction of haptoglobin, ceruloplasmin, fibrinogen, lysozyme in blood serum. 2. An increase of the indexes of phagocytic activity of neutrophils, content of haptoglobin, ceruloplasmin and fibrinogen in the conditions of the long-term ihflu- ence of least toxic among all studied chemical compounds - OENP4 and CM-OENP4 in a dose 1/100 DL50 is the protectivly-compensatory reaction of the rats organism. 3. The long-term influence of OENP and their derivatives in doses 1/10 and 1/100 causes an immunotoxic effect, results in disturbances of protective function of the immune system. Cumulation of changes of separate compartments of an immune defence in the conditions of the long-term influence of studied chemical compounds, probably, is realized by violation of structural integrity and functional wholeness of the immune system. 4. Consideration of die mechanisms of immunotoxic action of OENP and their derivatives is necessary at the choice of method of prevention and treatment of intoxications in persons which contact by them in the conditions of production and environment, and development of methods of early diagnostics and prevention of die occupationally and ecologically conditioned pathology. |
| URI: | https://repo.knmu.edu.ua/handle/123456789/7805 |
| Appears in Collections: | Наукові праці. Кафедра фізіології |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Nauka i Studia.pdf | 1,57 MB | Adobe PDF |  View/Open |
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