Effects of S-adenosyl-L-methionine for the treatment of metabolic-associated steatotic liver disease

Abstract

Objective – to determine the likely effect of S-adenosyl-L-methionine (SAMe) on the clinical course, liver enzymatic activity (the levels of Aspartate aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-Glutamyl Transpeptidase (GGT), Alkaline phosphatase (ALP)), Nonalcoholic steatohepatitis (NASH) activity and influence on the liver fibrosis (LF) stage in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).