Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/29802
Title: | Insulin-like growth factors in the serum of patients with papillary thyroid cancer |
Authors: | Pidchenko, Nataliia Krasnoselskyi, Mykola Mitriaieva, Nataliia Grebenik, Lidiya Astapieva, Olha Grushka, Ganna Paskevych, Olga Fedulenkova, Yuliia Myroshnychenko, Mykhailo |
Keywords: | insulin-like growth factor-2 papillary thyroid cancer insulin-like growth factor-1 blood serum |
Issue Date: | Aug-2021 |
Citation: | Insulin-like growth factors in the serum of patients with papillary thyroid cancer / N. S. Pidchenko, M. V. Krasnoselskyi, N. A. Mitriaieva, L. V. Grebenik, O. M. Astapieva, G. V. Grushka, O. I. Paskevych, Y. Ya. Fedulenkova, M. S. Myroshnychenko // Wiadomosci Lekarskie. – 2021. – Volume LXXIV, issue 8. – Р. 1925–1930. |
Abstract: | The aim is to study the level of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-2 (IGF-2) in the blood serum of patients with papillary thyroid cancer, depending on the main clinical and morphological features of the disease. There was found a relationship between the expression of IGF-1, IGF-2 and insulin: at elevated levels of insulin> 24.9 μIU/ml, IGF-1 increases 4.2 times, and IGF-2 – 2.5 times. Evaluation of the relationship between the level of IGF-1 and IGF-2 and cervical lymph node involvement shows that in the absence of lesion (N0) there is an increase in these indicators by 2.2 and 1.8 times, respectively. The signaling system of insulin-like growth factors (IGF-1 and IGF-2) plays an important role in the occurrence and progression of malignant tumors. It is especially true for papillary thyroid cancer, so its components can be considered as potential diagnostic and prognostic markers of the disease and targets for anticancer therapy. |
URI: | https://repo.knmu.edu.ua/handle/123456789/29802 |
Appears in Collections: | Наукові праці. Кафедра загальної та клінічної патофізіології імені Д.О. Альперна |
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