Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/26907
Title: | Time course of endothelial dysfanction and atherothrombosis markers in patients with acute myocardial infarction with ST segment elevation and type 2 diabetes mellitus depending on reperfusion therapy approach |
Authors: | Minukhina, Diana Babadzhan, Volodymyr Minukhin, Dmytro Yevtushenko, Denis Tverezovskiy, Mihail Kudrevych, Oleksandr |
Keywords: | acute myocardial infarction type 2 diabetes mellitus endothelial dysfunction asymmetric dimethylarginine plasminogen activator inhibitor type 1 percutaneous coronary intervention (PCI) |
Issue Date: | Jan-2020 |
Citation: | Time course of endothelial dysfanction and atherothrombosis markers in patients with acute myocardial infarction with ST segment elevation and type 2 diabetes mellitus depending on reperfusion therapy approach / D. Minukhina, V. Babadjan, D. Minukhin [et al.] // Wiadomości Lekarskie. – 2020. – Т. 73, nr 1. – S. 123–127. – DOI: 10.36740/WLek202001124. |
Abstract: | The aim: To evaluate the levels of plasminogen activator type 1 inhibitor, asymmetric dimethylarginine and endothelial nitric oxide synthase on day 10-14 in patients, depending on the presence or absence of concomitant type 2 diabetes and the type of reperfusion therapy. Materials and methods: The study involved 130 patients with acute myocardial infarction, divided into 2 groups: Group 1 consisted of patients with acute myocardial infarction with type 2 diabetes mellitus (n = 73), Group 2 comprised patients with acute type 2 diabetes mellitus (n = 57). The quantitative content of IAP-1 was determined by enzyme- linked immunosorbent assay using a commercial test system manufactured by Technoclone PAI-1 ELISA Kit (Austria), NOS – Enzyme-Linked Immunosorbent Assay (ELISA) Kit for Nitric Oxide Synthase Endothelial (NOS) ADMA ELISA Kit (Austria). Results and conclusions: Percutaneous coronary intervention contributes to a significant reduction in the content of ADMA, which is a marker of endothelial dysfunction and increase NOS on the 10-14th day of acute myocardial infarction compared with standard therapy. During PCI, the level of IAP-1 did not significantly change in the time course of treatment due to post-inflammatory and post-traumatic activation of platelets in the vascular wall. |
URI: | https://repo.knmu.edu.ua/handle/123456789/26907 |
Appears in Collections: | Наукові праці. Кафедра внутрішньої медицини № 2 і клінічної імунології та алергології ім. ак. Л.Т. Малої |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
TIME COURSE OF ENDOTHELIAL DYSFUNCTION .pdf | 912,96 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.