The misbalance between pro-inflammatory IL-1𝛽 and anti-inflammatory IL-4 in patients with chronic generalized periodontitis

Abstract

The research in question demonstrates lipoflavon capability to normalize homeostasis of the oral cavity, normalize misbalance of cytokines in periodontal tissues, thus retarding process of inflammation and destruction of tissues and improving reparation of periodontal structures. High therapeutic efficiency of the liposomal quercetin-lecithin complex for patients with chronic generalized periodontitis, especially that of initial-I degrees of severity was shown to be determined by anti-inflammatory, immunomodulating and periodontoprotecting effects. This allows to recommend lipoflavon for local application as pathogenetically substantiated drug in treatment of generalized periodontitis.