The influence of sodium salts of carboxymethylates of oxyethylated isononylphenols on the neutralizing function of the liver in a subacute toxicological experiment
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Marakushyn, Dmytro
Karmazina, Iryna
Isaieva, Inna
Hloba, Nataliia
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Abstract
The study was conducted as a part of research work “Biochemical mechanisms of the development of dismetabolic processes under the influence of chemical environmental factors”. The purpose of the present work was to study the effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment and to reveal a potential danger for homoitherms and human beings. The object of the study were the white rats of WAG population. The effects produced by sodium salts of carboxymethylates of oxyethylated isononylphenols of such brands as AFS 9-4 КМ, AFS 9-6 КМ, AFS 9-10 КМ on the state of the microsomal monooxygenase system of hepatocyte detoxification and on the conjugation reaction in conditions of a subacute experiment were studied. It was set that studied compounds during their subacute influence in a toxicological experiment stimulated the hydroxyling microsomal monooxygenase system of hepatocytes and inhibited reactions of the formation of glucuronid and glutathione conjugations against a background of more active processes of the formation of acetyl conjugation, higher levels in the content of CoA-SH, acetyl-CoA and ketone bodies.
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These results suggest the misbalance between prooxidant and antioxidant systems towards prevalence of prooxidants and activation of processes with the involvement of free radicals which probably leads to the oxidative stress. Eventually, the harmful effect of xenobiotics might result in mutation of cells genome, progression of malignization, cellular necrosis and overgrowth of connective tissue. Therefore, compensation of oxidative stress, which is accepted as an important reason of pathology caused by environmental factors in persons who was dealing with manufacture chemicals for a long time, is of great practical importance. Obtained results are highly relevant to be taken in account in laboratory tests as early diagnostic criteria indicating misbalance of oxidative homeostasis of an organism in conditions of sodium salts of carboxymethylates of oxyethylated isononylphenols effecting.
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The influence of sodium salts of carboxymethylates of oxyethylated isononylphenols on the neutralizing function of the liver in a subacute toxicological experiment / D. Marakushyn, I. Karmazina, I. Isaeva, N. Hloba // Georgian medical news. – 2018. – № 10 (283). – Р. 140–144.