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http://repo.knmu.edu.ua/handle/123456789/21215
Title: | The effect of a complex of active metabolites of vitamin D3 with vikasol on the periodontal state of rats |
Authors: | Skiba, A. Schnеider, S. Tkachenko, E. Savelyeva, N. |
Keywords: | cholecalciferol active metabolites of vitamin D3 vikasol model of periodontitis rats |
Issue Date: | 2018 |
Citation: | The effect of a complex of active metabolites of vitamin D3 with vikasol on the periodontal state of rats / A. V. Skiba, N. N. Savelyeva, S. A.Schnеider, E. K. Tkachenkо // Journal of Education, Health and Sport. – 2018. – № 8. – Р. 336–342. |
Abstract: | Purpose of the study. The study of the periodontoprotective properties of the complex of a mixture of active metabolites of cholecalciferol - 1,25 (OH)2D3 and 24,25(OH)2D3 with a synthetic analogue of vitamin K - vikasol in experimental periodontitis in rats. Materials and methods The study was carried out on 18 white male rats for 1.5 months. age, divided into 3 groups. Group 1 (4 individuals) comprised intact rats. In the rats of the 2nd and 3rd groups (7 individuals each), the parodontitis model was reproduced by oral administration of a 10% solution of pelentane, and also by replacing drinking water with a 2% solution of EDTA ad libitum. In group 3, rats were injected daily with a mixture of hormonal forms of vitamin D3 (1,25 (OH)2D3 and 24,25(OH)2D3) against a background of combined effects of pelentane and EDTA. The duration of the experiment was 60 days. Results and conclusions. It is established that the complex of a mixture of two hormonal-active forms of cholecalciferol with vikasol has significant periodontoprotective properties. The obtained data substantiate the inclusion of vitamin D3 in the composition of perioodontoprotective agents in the treatment of periodontitis. |
URI: | https://repo.knmu.edu.ua/handle/123456789/21215 |
ISSN: | 2391-8306 |
Appears in Collections: | Наукові праці. Кафедра стоматології |
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