The relation between galectin-3 concentration and coronary artery atherosclerotic lesions severity in patients with acute myocardial infarction and abdominal obesity

Abstract

Despite the improvement and progressive development of diagnostic and therapeutic approaches, ischemic heart disease (IHD) is one of the leading causes of morbidity and mortality worldwide. A number of traditional scales, such as the GRACE, TIMI scale, are currently used as objective non-invasive means for assessing the severity of coronary artery disease. Nowadays, engaging in routine practice of new parameters is considered as a promising direction of modern medicine. One of such parameters is galectin-3, which is involved in cell differentiation, fibrosis and immune-inflammation. The aim is to study the state of the coronary arteries in patients with acute myocardial infarction and concomitant obesity by angiography and an assessment of the presence and character of the relationship between atherosclerotic lesions of coronary arteries, calculated by Gensini score, and the concentration of galectin-3.