Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/19429
Title: | Disorders of water-electrolytemetabolism in pulmonary edema under inhibition of the renin-angiotensin-aldosterone system |
Authors: | Tiupka, Tetiana Zalyubovska, Olga Zlenko, Victor Avidzba, Julia Lytvynenko, Mycola Minaieva, Alina |
Keywords: | pulmonary edema angiotensin-converting enzyme inhibitors water-electrolyte metabolism |
Issue Date: | 2018 |
Citation: | Disorders of water-electrolytemetabolism in pulmonary edema under inhibition of the renin-angiotensin-aldosterone system / T. I. Tiupka, O. I. Zalyubovska, V. V. Zlenko, Yu. N. Avidzba, M. I. Litvinenko, A. O. Minaieva // Journal of Education, Health and Sport. – 2018. – Vol. 8, N 2. – P. 256–262. |
Abstract: | The aim of the study was to study the disorders of water-electrolyte metabolism in pulmonary edema under conditions of inhibition of RAAS by ACE inhibitors. Studies were performed on 70 white rats weighing 160-180 g on two models of pulmonary edema: hemodynamic (adrenaline) and acute toxic. In rats with hemodynamic pulmonary edema the pulmonary coefficient increased 3.3 times as compared with the intact control, where it was 0.68 %. With acute toxic edema, this indicator also increased, but to a lesser extent – 2.4 times. We established that the minute diuresis in animals with hemodynamic pulmonary edema decreased by 1.9 times, and with acute toxic edema – by 1.5 times. There was also a decrease in the concentration of sodium in the urine in groups of animals with hemodynamic edema and with acute toxic edema in 1.5 and 1.3 times, respectively. The use of ACE inhibitors for pulmonary edema leads to a decrease in the degree of their hyperhydration and normalization of water-electrolyte homeostasis. Compared with enalapril, zofenopril had a more pronounced anti-edematous effect in both hemodynamic and acute toxic edema of the lungs. Key words: pulmonary edema, angiotensin-converting enzyme inhibitors, water-electrolyte metabolism. |
URI: | https://repo.knmu.edu.ua/handle/123456789/19429 |
Appears in Collections: | Наукові праці. Кафедра клінічної лабораторної діагностики |
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Disorders of water-electrolytemetabolism in pulmonary edema.doc | 61,5 kB | Microsoft Word | View/Open |
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