Muscle strength reduction in patients with combined course of diabetes mellitus and osteoporosis

Abstract

Among patients with diabetes mellitus, the prevalence of osteoporosis reaches almost 35%, which increases the risk of complications and impairs the quality of life. Modern ideas about the mechanism of development of this comorbidity are the infuence of prolonged hyperglycemia and insulin resistance on the function and quantity of osteoblasts, vitamin D metabolism and accumulation of AGE-products that are embedded in the bone matrix and thus damage it.