Кафедра радіології та радіаційної медицини
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Item Clinical significance of ultrasonography in evaluation of morphofunctional state of liver and portohepatolienal bloodstream in chronic diffuse liver diseases(2015-06) Fedulenkova, YuliiaAbstract: In randomized three-phase prospective cohort controlled research which included 2564 persons with chronic diffuse liver diseases (1865 cases of fatty liver disease, 462 cases of chronic hepatitis, 100 cases of liver cirrhosis) and 137 healthy controls, the clinical significance of ultrasonography in quantitative evaluation of liver parenchyma morphofunctional state and portohepatolienal bloodstream in patients with chronic diffuse liver diseases was estimated. Twenty-seven ultrasound and two additional, derived from laboratory tests index parameters were testified for the grounding to be included into diagnosis-prognostic algorithm for patients with this pathology, which has been developed, validated and recommended for practical application. Further perspectives are related to fundamental logico-statistical analysis of the data for development of mathematic model of pathologic process and its application to practical health care service.Item Clinico – pathogenetic reasoning of echography and computed tomography role in diagnosis of chronic diffuse liver disease(2015-06) Fedulenkova, YuliiaAbstract: In three-stage prospective cohort controlled research of 2876 persons with chronic diffuse liver diseases (2076 cases of fatty liver disease, 509 cases of chronic hepatitis, 139 cases of liver cirrhosis) and 152 healthy controls the clinical significance of radiation methods of investigation in quantitative evaluation of liver morphofunctional state in patients with chronic diffuse liver diseases was estimated. Diagnosis-prognostic algorithm for patients with this pathology was developed, validated and recommended for practical application. Further perspectives are related to detailed chronic diffuse liver diseases stratification by intensity of steatosis (in fatty liver disease), activity (in chronic hepatitis), fibrosis (in chronic hepatitis and liver cirrhosis).