Кафедра медичної та біоорганічної хімії
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Browsing Кафедра медичної та біоорганічної хімії by Subject "3,4-dihydropyrimidine"
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Item Synthesis of Substituted 5-(1,2,4-Oxadiazol-5-yl)-3,4- dihydropyrimidine-2(1H)-thiones(American Chemical Society, 2009) Kharchenko, Juliya; Detistov, Oleksandr; Orlov, ValeriyWe have developed a liquid-phase route for combinatorial synthesis of novel substituted 5-(1,2,4-oxadiazol-5-yl)-3,4 dihydropyrimidine-2(1H)-thiones. Biginelli-type three-component condensation of 1-(3 aryl-1,2,4-oxadiazol-5-yl)acetones, thiourea, and benzaldehydes is shown to result in new 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thione heterocyclic system. If salicylaldehydes are used in this reaction, a mixture of 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones and 11-(1,2,4-oxadiazol-5-yl)-2,3,5,6-tetrahydro-4H-2,6-methano-1,3,5-benzoxadiazocine-4-thiones is formed.