Наукові праці. Кафедра внутрішньої медицини № 3 та ендокринології
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Browsing Наукові праці. Кафедра внутрішньої медицини № 3 та ендокринології by Author "Filonenko, Maryna"
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Item A clinical case of idiopathic pulmonary arterial hypertension in patient with comorbid ischemic heart disease: the key stages of diagnosis(2014) Журавльова, Лариса Володимирівна; Філоненко, Марина Вячеславівна; Лопіна, Наталія Андріївна; Zhuravlyova, Larysa; Filonenko, Maryna; Lopina, NataliiaDespite the progress achieved in the development of new directions in the diagnosis and treatment of idiopathic pulmonary arterial hypertension, it remains one of the most severe and prognostically unfavorable diseases. The article presents a clinical case and an algorithm for diagnosis of this rare disease, in respect to the decision-making in clinical practice. The present case underscores the need to consider a broad differential diagnosis for marked dyspnea in mature patients, especially when the intensity of dyspnea is out of proportion to the severity of underlying heart or lung diseases, or when symptoms fail to subside as expected in response to conventional therapy. Early diagnosis of idiopathic pulmonary arterial hypertension is vitally important for initiating modern therapy in order to improve the quality and duration of life in such patients.Item A connection betweeen arterial hypertansion, dyslipidemia and activity of interleukin-6 in type 2 diabetes mellitus(2019) Zhuravlyova, Larysa; Sokolnikova, Nelia; Filonenko, MarynaPurpose. To determine the relationship between blood pressure (BP), lipid metabolism and levels of IL-1β and IL-6 in patients with type 2 diabetes mellitus (T2DM).Item Acute myocardial infarction and antecedent hypertension: the changes of selenium levels, antioxidant enzymes and their correlation with the level of cardiac biomarkers(2019) Zhuravlyova, Larysa; Filonenko, MarynaThe purpose of this study was to determine the relationship between the activity of antioxidant agents and the levels of cardiac biomarkers in patients with non-ST elevation myocardial infarction (NSTEMI) and antecedent hypertension (AH).Item Diabetic gallbladder, dyspepsia and metabolic effects(2015) Журавльова, Лариса Володимирівна; Моїсеєнко, Тетяна Анатоліївна; Філоненко, Марина Вячеславівна; Zhuravlyova, Larysa; Moiseenko, Tetiana; Filonenko, MarynaThe purpose of the study was to determine the functional state of the gallbladder (GB) in patients with type 2 diabetes mellitus (T2DM) in combination with metabolic syndrome (MS).Item Differential changes of cardiac biomarkers and lipid profile by gender in patients with acute myocardial infarction accompanied with non-alcohol steatohepatites(2014) Zhuravlyova, Larysa; Filonenko, MarynaDiagnosis and risk assessment of acute coronary syndrome in women has traditionally been more difficult, especially when taking into consideration the presence of metabolic disorders associated with non-alcoholic steatohepatitisItem The efficacy of combination of empagliflozin and metformin in patients with arterial hypertension and type 2 diabetes mellitus(2023) Zhuravlyova, Larysa; Filonenko, Maryna; Rogachova, Tetiana; Sokolnikova, NeliaTo determine the efficacy of combination of empagliflozin and metformin in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM).Publication Experience of phototherapy application in treatment of osteoarthritis in patients with diabetes mellitus(2019) Zhuravlyova, Larysa; Fedorov, Volodymyr; Filonenko, Maryna; Oliinyk, Mariia; Sikalo, Yuliia; Korobov, AnatoliiThe disorders of the musculoskeletal system take an important place among the chronic complications of diabetes mellitus. Their prevalence varies from 24 to 60% according to various sources. Taking into consideration the fact that the largest group of patients with diabetes are those of working age, an additional disorder of the musculoskeletal system further complicates the course of the disease, reduces performance, accelerates disability, worsens the psychological state and socio-economic status, and thus, lowers the quality of life.Item Formation of a doctor in the process of professionalization in terms of pedagogical science(2019) Filonenko, MarynaThe process of professionalization is of great interest for modern science because of its impact on human ontogenetic development; personal qualities, interests and abilities; formation of the subject of labor; creating the proper life plan; identification of the requirements that profession imposes to the person; the formation of professional consciousness and self-awareness. Since professional activity is implemented in the form of a certain social role, professional development creates the preconditions for "occupational development", which is also one of the areas of professionalization.Item Gender peculiarities of lipid profile and metabolic oxygen-dependent reactions in patients with acute myocardial infarction accompanied with non-alcoholic steatohepatitis(2013) Zhuravlyova, Larysa; Filonenko, MarynaIt is well known that prognosis of acute myocardial infarction (AMI) in women (taking into consideration the age correction) is more unfavorable than in men. That’s why studying of pathogenetic issues of AMI in women with metabolic disorders is highly important. The purpose of the research is to determine the gender peculiarities of lipid profile changes and the state of metabolic oxygen-dependent reactions in patients with AMI accompanied with NASH.Item The influence of liraglutide on the level of blood pressure in patients with arterial hypertension against the background of obesity and type 2 diabetes mellitus(2021) Zhuravlyova, Larysa; Sokolnikova, Nelia; Filonenko, Maryna; Rogachova, TetianaPurpose: to assess the effect of liraglutide on the level of blood pressure in patients with arterial hypertension and obesity against the background of type 2 diabetes mellitus.Item The association of lipid spectrum with the ESR1 gene polymorphism in postmenopausal women with arterial hypertension and type 2 diabetes mellitus(2016) Zhuravlyova, Larysa; Butova, Tetiana; Filonenko, Maryna; Volobuieva, IrynaThe purpose of the research was to determine the relationship between the level of serum lipids and polymorphism of the estrogen alpha receptor gene (ESR1) in postmenopausal women with hypertension and type 2 diabetes mellitus. Materials and methods. A total of 137 caucasian women residing in the territory of Kharkiv city and Kharkiv region were examined. Women were receiving an inpatient treatment at endocrinology and cardiology units of "Regional Clinical Hospital - Center for emergency medical care and disaster medicine" in Kharkiv. Patients were divided into the following groups: 1st - patients with type 2 diabetes mellitus (n = 30), 2nd - patients with arterial hypertension, grade 2-3 (n = 34), 3rd – comorbid hypertension of grade 2-3 and type 2 diabetes (n = 42). The control group included 31 women in early natural menopause, which had normal blood pressure, glycated hemoglobin (HbA1c) level below 6% and absent endocrine diseases. The age of examined patients varied between 45 and 60 years. The following indexes were measured to study the lipid profile: triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Using polymerase chain reaction (PCR) was determined ESR1 gene T397C polymorphism in DNA samples. Identification of polymorphisms led to three types of conclusions: normal homozygotes (TT), heterozygotes (TC) and homozygous mutation (CC). Results. Our research has shown that the presence of diabetes might contribute to the worsening of the blood lipid profile in postmenopausal patients.The changes of blood lipid profile were associated with predominance of heterozygous TC genotypes of ESR1 gene in postmenopausal patients.Postmenopausal women either with hypertension alone or with comorbid course of hypertension and type 2 diabetes are characterized by significant predominance of heterozygous TC polymorphism T397C of ESR1 gene. Also, these patients have more pronounced changes of the lipid profile. Conclusions. According to the results of our study, we proposed a marker for targeted prevention of cardiovascular disease in postmenopausal women, which is the identification of heterozygous TC genotype T397C polymorphism of ESR1 gene against the background of marked lipid profile changes. Целью исследования было определить взаимосвязь между уровнем липидов в сыворотке крови и полиморфизмом гена рецептора эстрогена альфа (ESR1) у женщин в постменопаузе с артериальной гипертензией и сахарным диабетом 2 типа. Материалы и методы. Обследовано 137 женщин, проживающих на территории г. Харькова и Харьковской области. Женщины получали стационарное лечение в эндокринологии и кардиологии "Областной клинической больницы - Центра экстренной медицинской помощи и медицины катастроф" г. Харькова. Пациентки были разделены на группы: 1-я - пациентки с сахарным диабетом 2 типа (n=30), 2-я - пациентки с артериальной гипертензией 2-3 степени (n=34), 3-я - гипертензия 2-3 степени и сахарный диабет 2 типа (n= 42). В контрольную группу вошла 31 женщина в начале естественной менопаузы, которая имела нормальное кровяное давление, уровень гликированного гемоглобина (HbA1c) ниже 6% и без эндокринных заболеванийя. Возраст обследованных колебался от 45 до 60 лет. Следующие показатели были измерены для изучения липидного профиля: триглицериды (ТГ), общего холестерина (ТС), холестерина липопротеинов высокой плотности (ЛПВП) и холестерина липопротеинов низкой плотности (ХС-ЛПНП). С помощью полимеразной цепной реакции (ПЦР) определяли T397C полиморфизм гена ESR1 в образцах ДНК . Идентификация полиморфизма привела к трем типам выводов: нормальный гомозиготы (ТТ), гетерозиготы (ТС) и мутационный гомозиготных (CC). Результаты. Наше исследование показало, что наличие диабета может способствовать ухудшению липидного профиля крови в постклимактерическом периоде изменения пациенток. Липидный профиль крови был связан с преобладанием гетерозиготного ТС генотипа гена ESR1 у женщин в постменопаузе. Женщины с артериальной гипертензией или с сопутствующим сахарным диабетом 2 типа характеризуются значительным преобладанием гетерозиготного TC полиморфизм T397C гена ESR1. Кроме того, эти пациенты имеют более выраженные изменения липидного профиля. Выводы. По результатам нашего исследования, мы предложили маркер для целенаправленной профилактики сердечно - сосудистых заболеваний у женщин в постменопаузе: выявление гетерозиготного генотипа TC T397C полиморфизма гена ESR1 на фоне изменений липидного профиля.Item The association of lipid spectrum with the esr1 gene polymorphism in postmenopausal women with arterial hypertension and type 2 diabetes mellitus(2017) Журавлева, Лариса Владимировна; Бутова, Татьяна Сергеевна; Филоненко, Марина Вячеславовна; Волобуева, Ирина Анатольевна; Zhuravlyova, Larysa; Butova, Tetiana; Filonenko, Maryna; Volobuieva, IrynaЦелью исследования было определить взаимосвязь между уровнем липидов в сыворотке крови и полиморфизмом гена рецептора эстрогена альфа (ESR1) у женщин в постменопаузе с артериальной гипертензией и сахарным диабетом 2 типа. Материалы и методы. Обследовано 137 женщин, проживающих на территории г. Харькова и Харьковской области. Женщины получали стационарное лечение в эндокринологии и кардиологии "Областной клинической больницы - Центра экстренной медицинской помощи и медицины катастроф" г. Харькова. Пациентки были разделены на группы: 1-я - пациентки с сахарным диабетом 2 типа (n=30), 2-я - пациентки с артериальной гипертензией 2-3 степени (n=34), 3-я - гипертензия 2-3 степени и сахарный диабет 2 типа (n= 42). В контрольную группу вошла 31 женщина в начале естественной менопаузы, которая имела нормальное кровяное давление, уровень гликированного гемоглобина (HbA1c) ниже 6% и без эндокринных заболеванийя. Возраст обследованных колебался от 45 до 60 лет. Следующие показатели были измерены для изучения липидного профиля: триглицериды (ТГ), общего холестерина (ТС), холестерина липопротеинов высокой плотности (ЛПВП) и холестерина липопротеинов низкой плотности (ХС-ЛПНП). С помощью полимеразной цепной реакции (ПЦР) определяли T397C полиморфизм гена ESR1 в образцах ДНК . Идентификация полиморфизма привела к трем типам выводов: нормальный гомозиготы (ТТ), гетерозиготы (ТС) и мутационный гомозиготных (CC). Результаты. Наше исследование показало, что наличие диабета может способствовать ухудшению липидного профиля крови в постклимактерическом периоде изменения пациенток. Липидный профиль крови был связан с преобладанием гетерозиготного ТС генотипа гена ESR1 у женщин в постменопаузе. Женщины с артериальной гипертензией или с сопутствующим сахарным диабетом 2 типа характеризуются значительным преобладанием гетерозиготного TC полиморфизм T397C гена ESR1. Кроме того, эти пациенты имеют более выраженные изменения липидного профиля. Выводы. По результатам нашего исследования, мы предложили маркер для целенаправленной профилактики сердечно - сосудистых заболеваний у женщин в постменопаузе: выявление гетерозиготного генотипа TC T397C полиморфизма гена ESR1 на фоне изменений липидного профиля.Item The biomarkers of myocardial injury and the state of metabolic oxygen-dependent reactions in patients with acute myocardial infarction accompanied with non-alcoholic steatohepatites(2013) Zhuravlyova, Larysa; Filonenko, MarynaPatients with non-alcoholic steatohepatitis (NASH) are known to have high prevalence and severity of acute myocardial infarction (AMI) due to the synergism of pathogenetic mechanisms of metabolic syndrome, coronary artery disease and arterial hypertension. A constant growth of percentage of patients with AMI accompanied with NASH is observed recently all around the world.Item The correlation between hemodynamic indexes, lipid metabolism and proinflammatory cytokines in patients with metabolic cardiomyopathy(2013) Zhuravlyova, Larysa; Sokolnikova, Nelia; Filonenko, MarynaThe contemporary clinical and experimental data prove the fact that even insignificant increase of blood pressure may favor the development of cardiovascular pathology in patients with diabetes mellitus type 2. The influence of combination of different myocardial injury factors in patients with metabolic cardiomyopathy associated with DM-2 and increased indexes of blood pressure remains understudiedItem The correlation between serum selenium levels and cardia biomarkers in patints with acute myocardial infarction(2016) Журавлева, Лариса Владимировна; Филоненко, Марина Вячеславовна; Zhuravlyova, Larysa; Filonenko, MarynaSelenium plays an important role in the antioxidant defense of myocardium both by being a part of enzyme glutathione peroxidase and operating independently.Item The dynamics of functional state of the heart in patients with acute myocardial infarction accompanied with non-alcoholic steatohepatitis(2012) Filonenko, Maryna; Zhuravlyova, LarysaChronic hepatobiliary pathology is known to be an independent factor, capable to influence the clinical course, complications occurrence and prognosis in patients with acute myocardial infarction. The presence of chronic liver diseases in patients with AMI worsens the derangements of intracardiac and systemic hemodynamics, decelerates the reparative processes in myocardium. A constant growth of percentage of patients with AMI accompanied with non-alcoholic steatohepatitis is observed recently all around the world. That’s why studying of dynamics of fuctional state of the heart in such patients is topical and important.Item The influence of Interleukin-1Β, carbohydrate and lipid metabolism on formation of myocardial diastolic dysfunction in type 2 diabetes mellitus(2015) Журавльова, Лариса Володимирівна; Філоненко, Марина Вячеславівна; Сокольнікова, Неля Володимирівна; Zhuravlyova, Larysa; Sokolnikova, Nelia; Filonenko, MarynaSummary: A total of 102 patients with type 2 diabetes and preserved left ventricular systolic function were examined in the endocrinology department of Kharkiv Regional Hospital. The following indexes were evaluated: body mass index, waist circumference, hip circumference, indexes of carbohydrate and lipid metabolism, and the concentration of IL-1β. All patients underwent echocardiography along with the determination of parameters of diastolic function. The results of statistical analysis showed that level of interleukin-1β, age, body mass index, waist to hip circumference ratio and the level of low-density lipoprotein take part in the formation of diastolic dysfunction.Item The influence of pressing hypertension on functional heart parameters in patients with myocardial infarction(2015) Журавльова, Лариса Володимирівна; Філоненко, Марина Вячеславівна; Zhuravlyova, Larysa; Filonenko, MarynaHypertension and coexisting left ventricular hypertrophy are known to significantly affect mortality after acute myocardial infarction (AMI). One of the possible keys to negative prognosis is higher risk of heart failure development, which is still discussed.Item The influence of proinflammatory cytokines on the formation of cardiometabolic disorders(2019) Sokolnikova, Nelia; Filonenko, MarynaThe prevalence of type 2 diabetes mellitus is increasing every year, and with each year the number of patients suffering from cardiovascular complications caused by diabetes is increasing as well. Type 2 diabetes often goes along with obesity or overweight, which greatly impairs cardiovascular outcomes for such patients. Diabetic cardiomyopathy is a specific lesion of the myocardium that occurs on the background of diabetes due to the activation of numerous pathogenetic mechanisms. None of the pathological processes in the body can sustain without the activation of proinflammatory cytokines. Therefore, we hypothesized that in patients with diabetic cardiomyopathy, especially in those with overweight, an increase of interleukin-1β and interleukin-6 contributes to the development of cardiometabolic complications and the formation of organic pathology of the myocardium. A total of 102 patients with diabetes type 2 and no severe diabetic complications were examined in the endocrinology department of the Kharkiv Regional Clinical Hospital. The following data were analyzed: anthropometric measurements, indicators of carbohydrate and lipid metabolism, the level of activity of pro-inflammatory cytokines interleukin-1β and interleukin-6; as well as the intensity of cardiometabolic disorders, assessed by echocardiography. A statistical analysis revealed an increase of interleukin-1β and interleukin-6 activity, starting from the early stages of the disease, as well as the direct participation of these cytokines in the formation and progression of diabetic dyslipidemia and hyperinsulinemia, which allows us to consider them as the markers of metabolic disorders in patients with diabetes type 2.Item The influence of superoxide dismutase activity on the extent of myocardial injury and left ventricular remodeling in patients with acute myocardial infarction(2019) Zhuravlyova, Larysa; Filonenko, MarynaSuperoxide dismutase (SOD) is an important representative of enzymatic antioxidant system and its low levels are considered to be an independent predictor of cardiac death. The purpose of this study was to determine the influence of SOD activity on the extent of myocardial injury and subsequent left ventricular (LV) remodeling in patients with acute myocardial infarction (AMI).