Наукові праці. Кафедра фізіології
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Browsing Наукові праці. Кафедра фізіології by Author "Cherniakova, A."
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Item Dynamics of cytokines concentrations in blood serum of larynx squamous carcinoma patients(Joint Meeting of the American Physiological Society and the Physiological Society, 2016-07-29) Karmazina, Iryna; Cherniakova, A.; Isaieva, Inna; Hloba, NataliiaThe pluripotent role of “cytokines network” in inflammation and tumor dissemination is still the issue of the day. Cytokine families are investigated to find out the reliable markers for the prognosis and monitoring of the course of cancer on the basis of the correlation between their concentrations in the blood serum and stages of cancer disease. The aim of our research was to investigate concentrations of TNF-α, IL-1β, IL-6 (proinflammatory), IL-4, IL-1RA (antiinflammatory) in blood serum of patients with inflammation and different stages of squamous epithelium carcinoma of the larynxItem Role of electron microscopy in early diagnostics of squamous cell papiloma malignization(Дніпропетровська медична академія МОЗ України, 2016-10) Karmazina, Iryna; Lukashova, O.; Cherniakova, A.; Isaieva, Inna; Hloba, NataliiaSquamous cell papilloma of larynx belongs to the obligate precancer and comprises about 50% of all benign laryngeal tumors. Questions about pathogenesis of squamous cell papilloma and its malignant transformation are the actual problem of modern o to rh i n o 1 ary n go logy p ract i ce. The objective of the work was to carry out the comparative research of squamous cell papilloma of larynx in different morphological levels. 18 patients with diagnosis ofneoplasm of larynx, papilloma were examined. To specify the diagnosis the cytological research of touch smears from tumor’s surface and histological research of tissue samplings were carried out (Chandra Grubb. 1988). In 5 cases malignization of squamous cell papilloma was determined and conclusion aboutpresence of squamous cell cancer was made; in 13 cases morphological picture of tumor corresponded to squamous cell papilloma. Ultrastructure of researched papillomas was examined with help of standard methods of electron microscopy (Harris J.R., 1991).