Browsing by Author "Drobova, Nadiia"

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A clinical case report of cystic fibrosis and liver cirrhosis in a child
(2018) Klymenko, Viktoriia; Piontkovska, Oksana; Pasichnyk, Olena; Drobova, Nadiia; Yanovska, Katerina; Bevz, Sergiy; Sindeeva, Nataliia
Allergic rhinitis symptoms prevalence In children of Kharkiv
(2021) Klymenko, Viktoriia; Karpushenko, Juliia; Drobova, Nadiia; Kozhyna, Olga
The purpose of the study was to identify the prevalence of allergic rhinitis (AR) symptoms in children of Kharkiv and to establish the dynamics of symptoms since 1998. The study conducted in 2015–2017 is phase IV of the international ISAAC program. 5735 children were interviewed, including 3238 children aged 6–7 years and 2197 children aged 13– 14 years. The incidence of non-cold-related sneezing was found in 14.7 % and 16.1 %, respectively; during the past 12 months similar problems with nose breathing were noted in 9.1 % and 9.9 %; accompanied by conjunctivitis – in 3.4 % and 4.8 % of children of 6–7 and 13–14 years, respectively. Most patients had seasonal exacerbations and mild/moderate rhinitis. AR diagnosis was verified in 12.2 % and 11.3 % of children, respectively. Decreasing of AR symptoms prevalence was found in children of all ages. The dynamics of AR symptoms prevalence, "eye" symptoms over the past 20 years show a probable decrease in all indicators, which can be explained by the widespread introduction in medical practice of screening methods for the disease diagnosing, activation of primary and secondary prevention.
Characteristics of immune status in children with cystic fibrosis
(2020) Klymenko, Viktoriia; Piontkovska, Oksana; Drobova, Nadiia; Pasichnyk, Olena; Shelest, Svitlana
Characteristics of sensitization to pollen, domestic, food allergens in children with cystic fibrosis
(2020) Drobova, Nadiia; Amankar, Utkarsha
Comorbidity and impact of bronchial asthma to gastroesophageal reflux disease in children
(2024) Карпушенко, Юлія Валентинівна; Кarpushenko, Yuliia; Фролова, Тетяна Володимирівна; Frolova, Tetyana; Дробова, Надія Миколаївна; Drobova, Nadiia; Ащеулов, Олександр Михайлович; Ashcheulov, Oleksandr
Gastroesophageal reflux disease (GERD) is a highly comorbid disease with bronchial asthma (BA). The relationship between GERD and BA is complicated and controversial. Aim: to analyze impact factors of BA and GERD in children with comorbid pathology for the further development of early diagnostic and preventive measures. Materials and methods. 81 children (aged 6 to 18 years) were involved in the study and divided into two groups: children with GERD and BA as a main group (n=27) and children with GERD and without allergy as a control group (n=54). The verification of diagnoses was carried out according to the unified clinical protocols of medical care. The results were processed using nonparametric statistical methods. Results. Esophageal motility disorders (EM) were detected in 100% of patients with BA, regardless of the severity. Inflammatory changes of the esophageal mucosa (EM) were equally frequently detected in patients with mild and moderate persistent BA, and were absent in patients with severe BA. GERD was diagnosed in 44.4% of patients with BA. 25.0% of patients had the erosive form of GERD, 25.0% — non-erosive GERD, 50.0% — endoscopically negative GERD, in the control group — 33.0%, 35.0%, 32.0% respectively. Conclusion. All patients with BA had esophageal motility disorders. GERD was diagnosed in 44.4%. Inflammatory changes of EM (erosive and non-erosive forms of GERD) were detected in 22.0% of patients with mild and moderate forms of BA, and in severe forms of BA — endoscopically negative GERD. The frequency of inflammatory changes reached 68.0% in the control group. The research was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work. The informed consent of children's parents was obtained for conducting the studies. No conflict of interests was declared by the authors.
Congenital immunodeficiency disorders in the pediatric practice
(2022) Lupaltsova, Olga; Drobova, Nadiia; Servetnyk, Anzhela
Introduction. Congenital immunodeficiency disorders are genetic pathology that affect the immune system function and is important problem of modern medicine.Material and methods. This dates are performed the clinical case of the child with congenital complement deficiency. Results. Patient was diagnosed with allergic skin symptoms (atopic dermatitis, eczema), persistent bacterial infections of the upper and lower respiratory tract, late teething, diarrhea, chronic diseases of the gastrointestinal tract. That signs were manifestations of immunodeficiency states. During clinical and paraclinical examination the following data was detected in immunological blood test: decreased levels of CD3+-lymphocytes, CD3+CD8+-cytotoxic lymphocytes, CD19 +-lymphocytes. Gene panel of boy identifies one pathogenic variant in С8B (c. 1282C>T (p.Arg428*)), heterozygous, one pathogenic variant in C3 (c.2402C>T (p.Thr801Met)), heterozygous, which is associated with autosomal recessive and dominant. Uncertain significance variants were detected. Genetic signs in family members were also detected. Conclusion. Genetic testing for identifying of congenital defects is very important in primary immunodeficiency diagnostic process.
Cystic fibrosis social aspects in Ukraine
(National Health as Determinant of Sustainable Development of Society. Editors: Nadiya DUBROVINA & Stanislav FILIP. Monograph. School of Economics and Management in Public Administration in Bratislava, 2021) Klymenko, Viktoriia; Piontkovska, Oksana; Pasichnyk, Olena; Drobova, Nadiia
Cystic fibrosis (CF) is a genetically determined pathology. It belongs to the orphan diseases group. CF is an important social problem not only in Ukraine but also all over the world. The main social problems of CF patients in Ukraine are insufficient and late diagnosis of the disease, lack of genetic passport of most patients, severe disease course with psychological problems in the family, lack of access to high-tech treatment algorithms (gene therapy, lung transplantation), short life expectancy and difficult financial position. In recent years, there have been the number of positive changes in the treatment and management of CF patients in Ukraine. Implementation of international standards of treatment and care is the only way to improve the life quality of CF patients.
Features of Cystic Fibrosis Course in Children Depending on Interleukin-4 Gene Mutation
(2018) Drobova, Nadiia
Cystic fibrosis (CF) course features depend not only on the difference in CF transmembrane conductance regulator gene mutations, but also onother gene modifiers. Interleukin-4 (IL-4) gene is a one of gene modifiers. The aim of the present study was to improve medical care for patients with CF by clarifying the pathogenic role of IL-4 gene polymorphism in the course of the disease. The study involved examination of 42 children with CF and 54 practically healthy children as control group. Patient examination was carried out by the standard methods in the remission period. Determination of C589T polymorphism of IL-4 gene was carried out using polymerase chain reaction inreal time. DNA was isolated from buccal epithelium cells. Patients with IL-4 gene mutation (C589T) were characterized by more frequent primary manifestation of the respiratory signs, Staphylococcus aureus predominance within respiratory pathological microorganisms, the incidences of bronchiectasis and lung fibrosis, more severe liver lesions, elevated total serum immunoglobulin E level, elevated levels of the CD25 lymphocytes, circulating immune complex and reduced immunoglobulin A levels. The data demonstrate features of CF phenotype associated with IL-4 gene polymorphism.
Клінічне спостереження дитини, хворої на муковісцидоз
(2017) Klymenko, Viktoriia; Pasichnyk, Olena; Drobova, Nadiia; Yanovska, Katerina; Клименко, В.А.; Пасічник, О.В.; Дробова, Н.М.; Яновська, К.О.
У статті наведено клінічне спостереження дитини, хворої на муковісцидоз. Діагноз муковісцидозу встановлений своєчасно під час проведення неонатального скринінгу. Дитина отримувала базисну замісну ферментну терапію постійно. З 3-го місяця відмічено ураження респіраторної системи, колонізація Pseudomonas aeruginosa — з 7-го місяця, часті загострення бронхолегеневого процесу у вигляді пневмоній з формуванням бронхоектазів. Антибактеріальну терапію отримувала тільки під час перебування у стаціонарі та короткими курсами амбулаторно у зв’язку з соціальними причинами, що й стало причиною смерті дитини у віці 2 роки 5 міс.